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The source of urinary nitrosamines in patients with enterocystoplasties
T A Creagh1, D Picramenos, E T Smalley
1Academic Department of Urology, Guy's Hospital, London, UK.
Objective:
To assess the factors influencing urinary nitrosamine production in patients with enterocystoplasties.
Patients, Subjects And Methods:
The study comprised 100 patients with an enterocystoplasty, 20 patients with interstitial cystitis, 30 with infective cystitis and 120 control subjects drawn from hospital staff and out-patients. Urinary nitrosamine levels were measured and the urine samples cultured for microorganisms.
Results:
Nitrosamine levels were significantly higher only in patients with enterocystoplasties who also had higher urinary white cell counts or significant bacteriuria.
Conclusion:
Patients with an enterocystoplasty and significant bacteriuria are most at risk from potential nitrosamine-induced epithelial injury.