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Spinal anaesthesia with midazolam in the rat
M Bahar1, M L Cohen, Y Grinshpon
1Department of Anaesthesiology, Assaf Harofeh, Medical Centre, Zerifin, Israel.
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|February 1, 1997
Summary
Intrathecal midazolam, alone or with fentanyl, provides effective anesthesia for abdominal surgery in rats, comparable to lidocaine but without hemodynamic or respiratory side effects. This spinal anesthesia offers a safer alternative for surgical procedures.
Area of Science:
- Anesthesiology
- Pharmacology
- Surgical Research
Background:
- Intrathecal anesthesia is crucial for surgical procedures.
- Lidocaine is a common anesthetic, but can cause hemodynamic instability.
- Exploring alternative intrathecal agents like midazolam is important for balanced anesthesia.
Purpose of the Study:
- To evaluate intrathecal midazolam, alone or with fentanyl, for surgical anesthesia in an animal model.
- To compare its efficacy and safety to intrathecal lidocaine.
- To assess effects on consciousness, segmental anesthesia, and vital signs.
Main Methods:
- Sixty Wistar rats received chronic lumbar intrathecal catheters.
- Groups were administered intrathecal lidocaine, midazolam, midazolam with fentanyl, or fentanyl alone.
- Intravenous midazolam and inhaled halothane served as controls.
Main Results:
- Intrathecal midazolam (alone or with fentanyl) induced effective segmental sensory and motor blockade for laparotomy.
- Unlike lidocaine, midazolam groups showed no reduction in blood pressure or heart rate.
- No significant changes in arterial blood gases or respiratory rate were observed.
Conclusions:
- Intrathecal midazolam produces reversible, segmental, spinal antinociception.
- It provides anesthesia sufficient for abdominal surgery.
- Midazolam offers a potentially safer option for balanced spinal anesthesia.