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Additional predictive value of both left and right ventricular ejection fractions on long-term survival in idiopathic

Y Juillière1, G Barbier, L Feldmann

  • 1Cardiologie B, CHU Nancy-Brabois, Vandoeuvre-les-Nancy, France.

European Heart Journal
|February 1, 1997
PubMed

Insights

Right ventricular ejection fraction is a key predictor of survival in idiopathic dilated cardiomyopathy, complementing left ventricular ejection fraction. Assessing right ventricular function is crucial for managing patients with this condition.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Heart Failure Research

Background:

  • Idiopathic dilated cardiomyopathy (IDC) is associated with poor long-term outcomes.
  • Left ventricular ejection fraction (LVEF) is a primary survival predictor in IDC.
  • The prognostic significance of right ventricular (RV) function in IDC requires further elucidation.

Purpose of the Study:

  • To investigate the role of RV parameters, particularly RV ejection fraction (RVEF), in predicting survival in patients with IDC.
  • To determine if RVEF provides additional prognostic information beyond established markers like LVEF.

Main Methods:

  • Prospective study of 62 patients with IDC evaluated between 1990-1992.
  • Inclusion of hemodynamic assessment, thermodilution RVEF, and RV volume measurements.
  • Long-term follow-up to assess survival rates and identify predictors of outcome.

Main Results:

  • Patients presented with advanced symptoms (60% NYHA class III/IV) and common comorbidities like atrial fibrillation (19%) and left bundle branch block (35%).
  • Mean LVEF was 30% ± 10% and mean RVEF was 30% ± 16%.
  • Multivariate analysis identified both LVEF (P < 0.001) and RVEF (P < 0.004) as independent predictors of survival.

Conclusions:

  • RVEF is a significant complementary predictor of survival in idiopathic dilated cardiomyopathy.
  • Assessment of RV function, in addition to LV function, is important for comprehensive prognostic evaluation in IDC.
  • These findings underscore the clinical relevance of evaluating biventricular function for improved patient management.
Abstract

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