Sex-related pharmacokinetic and pharmacodynamic variations of lisinopril

The aim of the present study was to determine whether or not the pharmacokinetic and hemodynamic response to a 20 mg single oral dose of lisinopril was sex-dependent. Thirty-two young healthy volunteers (16 males and 16 females) were included in the trial. Blood samples to assess lisinopril plasma concentrations, determined indirectly by inhibition of the angiotensin converting enzyme (ACE) and hemodynamic variables, were obtained before and at different times following drug intake. No significant differences in pharmacokinetic parameters were observed between males and females. An hypotensive response was obtained between 2 and 10 h for systolic blood pressure and between 2 and 24 h for diastolic blood pressure. Again, no significant sex-related differences were noted. Lisinopril was well tolerated.