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Human immunodeficiency virus-related lymphoid proliferations
1Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Seminars in Diagnostic Pathology
|February 1, 1997
Summary
Human immunodeficiency virus (HIV) infection causes diverse lymphoid changes, particularly in children. This study details the histological features of these HIV-related lymphoid proliferations.
Area of Science:
- Pathology
- Immunology
- Virology
Background:
- Human immunodeficiency virus (HIV) infection is linked to various lymphoid abnormalities, including lymphadenopathy, abnormal lymphoid proliferations, and lymphomas.
- Specific lymphoid proliferation patterns are observed in the lungs and thymus of children with HIV.
- HIV-associated lymphoid proliferations can co-occur with opportunistic infections and viruses like Pneumocystis carinii, mycobacteria, EBV, and KSHV/HHV-8.
Purpose of the Study:
- To describe the histological characteristics of the spectrum of lymphoid proliferations associated with HIV infection.
- To highlight unique lymphoid changes in pediatric HIV cases.
Main Methods:
- Histopathological examination of lymphoid tissues from HIV-infected individuals.
- Review of clinical data and co-infections associated with lymphoid proliferations.
Main Results:
- Detailed description of the histological spectrum of HIV-related lymphoid proliferations.
- Identification of characteristic features in pediatric HIV-associated lymphoid changes.
- Association of lymphoid proliferations with specific infectious agents and viruses.
Conclusions:
- HIV infection induces a wide range of lymphoid alterations with distinct histological features.
- Understanding these histological patterns is crucial for accurate diagnosis and management of HIV-related lymphoid conditions.
- Co-infections play a significant role in the presentation of HIV-associated lymphoid proliferations.