Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atheroma as a neoplastic disease

D Rotman

    Medical Hypotheses
    |September 1, 1977
    PubMed
    Summary

    Atheroma, a hallmark of atherosclerosis, may be a type of leiomyosarcoma originating from arterial smooth muscle cells. This neoplastic transformation explains atherosclerosis pathogenesis by excessive enzyme production, leading to cell proliferation and arterial wall changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity.

    The Journal of biological chemistry·1989
    Same author

    Sialoresponsin and an antiviral action of ascorbic acid.

    Medical hypotheses·1978
    Same author

    Ascorbic acid, cell proliferation, and cancer.

    Lancet (London, England)·1972
    Same author

    Unsaturated fat and vitamin-E deficiency.

    Lancet (London, England)·1971

    Area of Science:

    • Cardiovascular Pathology
    • Oncology
    • Arterial Biology

    Background:

    • Atherosclerosis is a complex vascular disease characterized by plaque buildup.
    • The precise pathogenesis of atheroma formation remains incompletely understood.
    • Smooth muscle cells in the arterial tunica media play a critical role in vascular homeostasis and disease.

    Purpose of the Study:

    • To propose a novel hypothesis classifying atheroma as a leiomyosarcoma.
    • To explain the pathogenesis of atherosclerosis through a neoplastic disease model.
    • To elucidate the role of specific enzymes in atheroma development and arterial wall changes.

    Main Methods:

    • Conceptual hypothesis formulation based on existing literature.
    • Analysis of cellular and molecular mechanisms involved in atherosclerosis.
    • Comparison of atheroma characteristics with known features of leiomyosarcoma.

    Main Results:

    • Atheroma is hypothesized to originate from malignant transformation of arterial smooth muscle cells.
    • This transformation involves excessive production of hyaluronidase and other glycosaminoglycan hydrolases.
    • These enzymes facilitate cell detachment, proliferation, fibroblast hyperplasia, and subsequent collagenization, contributing to arterial sclerosis.

    Conclusions:

    • Viewing atheroma as a leiomyosarcoma offers a unifying explanation for atherosclerosis.
    • Enzyme-driven neoplastic processes in the tunica media are central to atheroma pathogenesis.
    • This hypothesis provides a new framework for understanding and potentially treating atherosclerosis.

    Related Experiment Videos