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Binding of Cu2+, Zn2+, and Ni(2+)-GnRH complexes with the rat pituitary receptor
K Kochman1, A Gajewska, H Kochman
1Institute of Animal Physiology and Nutrition, Jabłonna, Poland.
Journal of Inorganic Biochemistry
|March 1, 1997
Abstract:
Complex of copper with the gonadotropin-releasing hormone, GnRH, competed more efficiently for the GnRH receptor than native GVRH, while complexes of nickel with GnRH and zinc with GnRH had slightly lower affinity. Copper ion added to the incubation mixture inhibited the buserelin binding to the receptor.