Human CD46 aberrant splicing in transgenic mice
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Updated: Oct 14, 2026
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
L C Mulder1, M Rossini, M Mora
1IRIS, The Chiron Biocine Immunobiological Research Institute, Siena, Italy.
Gene
|February 20, 1997
Abstract:
RNA analysis of mice transgenic for human CD46 reveals almost undetectable levels of the expected transcript and the accumulation of a 900 nt shorter species. cDNA cloning and sequence analysis of this variant demonstrate an aberrant splicing of the transgene RNA. This aberrant splicing is present at low levels in cells that normally express the gene, suggesting that the transgene is lacking regulatory elements influencing the abundance of the shorter transcript.
