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The surgical implications of primary hypercoagulable states
T M Bergamini1, J D Richardson
1Department of Surgery, University of Louisville School of Medicine, KY 40292, USA.
Insights
This report details hypercoagulable states, hereditary disorders causing thrombosis. It reviews diagnostic and treatment guidelines for conditions like protein deficiencies and antiphospholipid syndromes.
Area of Science:
- Hematology
- Genetics
Background:
- Primary hypercoagulable states are hereditary conditions leading to arterial and venous thromboses.
- These disorders involve deficiencies in proteins like antithrombin III, protein C, and protein S, or fibrinolytic issues.
Abstract:
Primary hypercoagulable states are hereditary disorders that result in arterial and venous thromboses. The purpose of this report is to present three patients with hypercoagulable states, and offer current guidelines for diagnosis and treatment. Primary hypercoagulable disorders such as antithrombin III, protein C and protein S deficiencies, fibrinolytic disorders such as decreased plasminogen levels and plasminogen activator deficiency, and antiphospholipid syndromes such as anticariolipin antibody and lupus anticoagulants will be reviewed. We will emphasize clinical characteristics that should prompt evaluation for hypercoagulation, appropriate laboratory tests for hypercoagulable disorders, and treatment. Other secondary and recently investigated hypercoagulable disorders, including heparin-associated thrombocytopenia, homocystinemia, lipoprotein (a), plasminogen activator inhibitor, and factor V Leiden, will also be reviewed.
