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In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test
1Medical Institute for General Hygiene and Environmental Health, Georg-August-Universität, Göttingen, Germany.
Archives of Toxicology
|January 1, 1997
Abstract:
The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1,400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.