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Fluctuation of endogenous TNF alpha concentration in plasma in advanced cancer patients
M Muc-Wierzgoń1, K Madej, M Baranowski
15th Department of Internal Medicine, Silesian Medical University, Bytom, Poland.
Journal of Biological Regulators and Homeostatic Agents
|January 1, 1996
Abstract
Objectives:
To test the hypothesis of a fluctuation of circulating levels of endogenous Tumor Necrosis Factor alpha (TNF alpha) in patients with advanced gastrointestinal cancer.
Methods:
Serum levels of TNF alpha were measured at 8 a.m., 3 p.m., midnight and 3 a.m. in 21 patients with advanced cancer.
Results:
Serum TNF alpha levels were substantially increased in patients with advanced cancer as compared to healthy subjects. Peak value appeared at 3 a.m., and gradually declined to very low levels in the afternoon (3 p.m.). Using cosinor least square methods we could not find the circadian rhythm of TNF alpha.