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Patterns of oncogene activation in human neuroblastoma cells
R Corvi1, L Savelyeva, M Schwab
1Deursches Krebsforschungszentrum, Abteilung Zytogenetik, Heidelberg, Germany.
Journal of Neuro-Oncology
|January 1, 1997
Abstract:
Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.