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Glomerulonephritis in the elderly

A M Davison1, P A Johnston

  • 1Department of Renal Medicine, St James's University Hospital, Leeds, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1996
PubMed
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Glomerulonephritis in elderly patients is increasingly diagnosed, with nephrotic syndrome being a common reason for kidney biopsy. This trend reflects improved investigation rather than a true rise in disease incidence.

Area of Science:

  • Nephrology
  • Geriatric Medicine
  • Pathology

Background:

  • Glomerulonephritis is a significant cause of kidney disease, particularly in older adults.
  • The incidence of glomerulonephritis in the elderly population has been observed to increase over time.

Purpose of the Study:

  • To analyze trends in glomerulonephritis diagnosis and kidney biopsy in patients over 60 years old.
  • To identify common causes and histological findings of glomerulonephritis in the elderly.

Main Methods:

  • Retrospective analysis of 7086 patient records from the MRC Glomerulonephritis Registry (1978-1990).
  • Focus on 1368 patients aged over 60 years at the time of kidney biopsy.
  • Categorization of biopsy indications and histological diagnoses.

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Main Results:

  • The proportion of patients over 60 undergoing kidney biopsy increased from 12% in 1978 to 30% in 1990.
  • Nephrotic syndrome (31%), acute renal failure (26%), and chronic renal failure (25%) were primary biopsy indications.
  • Membranous nephropathy (36.6%) was the most common histological finding in elderly patients with nephrotic syndrome.

Conclusions:

  • Glomerulonephritis in the elderly is not rare, and the apparent increase is likely due to enhanced diagnostic referrals.
  • Early investigation and biopsy are crucial for diagnosing glomerulonephritis in older patients.
  • Understanding histological patterns aids in managing elderly patients with kidney disease.