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Clobenzorex: evidence for amphetamine-like behavioral actions
R Young1, N A Darmani, E L Elder
1Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia/Virginia, Commonwealth University, Richmond 23298-0540, USA.
Pharmacology, Biochemistry, and Behavior
|February 1, 1997
Summary
Clobenzorex, an amphetamine derivative, shows central stimulant properties similar to amphetamine but is less potent. This finding is crucial for understanding its abuse potential in the illicit drug market.
Area of Science:
- Pharmacology
- Neuroscience
- Drug Abuse
Background:
- Clobenzorex, an N-substituted derivative of amphetamine, is found on the illicit market.
- Limited information exists on its pharmacology and abuse potential.
Purpose of the Study:
- To investigate the behavioral properties of clobenzorex.
- To determine if clobenzorex produces amphetamine-like effects.
Main Methods:
- Rats were trained to discriminate (+)amphetamine from vehicle.
- Stimulus generalization tests were conducted with clobenzorex.
- Locomotor activity and rearing frequency in mice were measured.
Main Results:
- Clobenzorex substituted for (+)amphetamine in rats, indicating similar behavioral effects.
- Clobenzorex was approximately 20 times less potent than (+)amphetamine in stimulus generalization.
- Clobenzorex induced locomotor stimulation and rearing in mice, but was less potent than (+)amphetamine and cocaine.
Conclusions:
- Clobenzorex possesses amphetamine-like central stimulant behavioral properties.
- Despite being weaker than (+)amphetamine, clobenzorex has potential for abuse.
- Further research is needed to fully characterize clobenzorex's pharmacological profile.