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Prognostic value from DNA quantification by static cytometry in breast cancer
1Department of Morphologic Sciences, Faculty of Medicine, University of Zaragoza, Spain.
Objective:
To determine if DNA quantification on fine needle aspiration (FNA) has predictive value in breast cancer.
Study Design:
Forty-nine patients with breast cancer were selected for this study because of their common characteristics. The smears were studied using image cytometry.
Results:
With the type of histogram and value of entropy, two large groups, with high and low degrees of malignancy, were obtained. Survival was utilized as a variable of interest. Kaplan-Meier survival curves for both groups were formulated, and the results were supported with statistical data.
Conclusion:
The survival differences between both groups were statistically significant (P < .001), thus demonstrating the predictive value of DNA quantification.
