Related Experiment Video
Updated: Aug 14, 2026
07:30
Creating Radio-cephalic Arteriovenous Fistula in the Forearm with a Modified No-Touch Technique
Published on: April 1, 2022
Ketoprofen and carotico-cavernous fistula
1University Department of Neurology, Queen Elizabeth Hospital, Birmingham, UK.
Cephalalgia : an International Journal of Headache
|February 1, 1997
Summary
Ketoprofen effectively relieved pain in a patient with a carotico-cavernous fistula when standard analgesics failed. This suggests ketoprofen
Area of Science:
- Neurology
- Vascular Surgery
- Pain Management
Background:
- Traumatic direct carotico-cavernous fistula presents a challenge for pain management.
- Standard analgesics like ibuprofen and codeine may not always provide adequate relief.
Observation:
- A patient with a traumatic direct carotico-cavernous fistula experienced persistent pain despite adequate doses of ibuprofen and codeine.
- Single doses of ketoprofen demonstrated reproducible pain alleviation in this patient.
Findings:
- Ketoprofen exhibited superior analgesic efficacy compared to ibuprofen and codeine in this specific clinical scenario.
- The mechanism for ketoprofen's enhanced efficacy may involve actions beyond cyclooxygenase inhibition.
Implications:
- This case highlights ketoprofen as a potential therapeutic option for refractory pain associated with carotico-cavernous fistulas.
- Further research into ketoprofen's unique pharmacological profile could elucidate pathways involved in vascular headache pathogenesis.
