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Related Experiment Videos

Calcifying fibrous pseudotumor

M Fukunaga1, Y Kikuchi, Y Endo

  • 1Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.

Pathology International
|January 1, 1997
PubMed
Summary

A rare calcifying fibrous pseudotumor was found in a young woman's groin. This benign tumor showed specific collagen patterns and spindle cell markers, with no recurrence after surgery.

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Area of Science:

  • Pathology
  • Oncology
  • Dermatology

Background:

  • Calcifying fibrous pseudotumor (CFP) is a rare mesenchymal neoplasm.
  • CFP typically presents as a slowly growing mass with characteristic histopathological features.

Observation:

  • A 20-year-old female presented with a 3-month history of a 2.0 cm subcutaneous mass in the groin.
  • Microscopic examination revealed dense collagen bundles, spindle cells, lymphoid follicles, and dystrophic microcalcifications.
  • Immunohistochemistry showed spindle cell positivity for vimentin and alpha-smooth muscle actin, and negativity for other markers.

Findings:

  • The tumor exhibited a diploid DNA content with a low S-phase fraction (2.5%) via flow cytometry.
  • Histological and immunohistochemical findings were consistent with calcifying fibrous pseudotumor.
  • The spindle cells were positive for vimentin and alpha-smooth muscle actin, suggesting myofibroblastic differentiation.

Implications:

  • This case expands the understanding of CFP presentation in young adults.
  • The benign nature and favorable prognosis of CFP are highlighted.
  • Accurate diagnosis through histopathology and immunohistochemistry is crucial for appropriate management.

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