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Illudinic acid, a novel illudane sesquiterpene antibiotic
C Dufresne1, K Young, F Pelaez
1Merck Research Laboratories, Rahway, New Jersey 07065, USA. claude_dufresne@merck.com
Journal of Natural Products
|February 1, 1997
Abstract:
A novel illudane sesquiterpene antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 micrograms/mL. It also shows L-1210 cytotoxicity with an IC50 of 10-15 micrograms/mL.