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Related Experiment Videos

Synaptic innervation density is regulated by neuron-derived BDNF

C G Causing1, A Gloster, R Aloyz

  • 1Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Canada.

Neuron
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

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Neuron-derived brain-derived neurotrophic factor (BDNF) influences neural circuits. Increased BDNF in mice led to greater synaptic connections, while its absence reduced them, showing BDNF regulates synaptic density.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Sympathetic neurons synthesize brain-derived neurotrophic factor (BDNF).
  • Preganglionic neurons express the full-length BDNF/TrkB receptor, suggesting a functional interaction.
  • The role of neuron-derived BDNF in regulating synaptic connections at the preganglionic-sympathetic neuron synapse was investigated.

Purpose of the Study:

  • To determine how neuron-derived BDNF affects synaptic innervation density.
  • To investigate the impact of altered BDNF levels on the development and structure of neuronal circuits.

Main Methods:

  • Utilized transgenic mice with manipulated BDNF synthesis (increased or eliminated).
  • Examined morphological changes in preganglionic neurons (cell bodies and axons).

Related Experiment Videos

  • Assessed synaptic innervation density onto sympathetic neurons.

    • Main Results:

    • Increased BDNF levels (2- to 4-fold) in transgenic mice resulted in hypertrophy of preganglionic cell bodies and axons.
    • Elevated BDNF also led to increased synaptic innervation of sympathetic neurons.
    • BDNF knockout mice (BDNF-/-) exhibited decreased preganglionic synaptic innervation to sympathetic neurons.

    Conclusions:

    • Neuronal neurotrophin synthesis, specifically BDNF, directly regulates neuronal circuitry.
    • BDNF plays a critical role in modulating synaptic innervation density.
    • These findings highlight BDNF's importance in shaping neural connectivity.