Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in rat brain gangliosides following active avoidance conditioning

H E Savaki, G M Levis

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1977
    PubMed
    Summary

    Rats trained in a Sidman avoidance task showed increased levels of polysialogangliosides in the hippocampus and neocortex. These findings suggest specific brain regions are affected by avoidance conditioning.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional imaging of the intraparietal cortex during saccades to visual and memorized targets.

    NeuroImage·2006
    Same author

    Frontal cortical areas of the monkey brain engaged in reaching behavior: a (14)C-deoxyglucose imaging study.

    NeuroImage·2005
    Same author

    Oculomotor areas of the primate frontal lobes: a transneuronal transfer of rabies virus and [14C]-2-deoxyglucose functional imaging study.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2004
    Same author

    Functional imaging of the primate superior colliculus during saccades to visual targets.

    Nature neuroscience·2001
    Same author

    The intraparietal cortex: subregions involved in fixation, saccades, and in the visual and somatosensory guidance of reaching.

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2001
    Same author

    Sokoloff's 14C-deoxyglucose method.

    Brain research bulletin·2000

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • Gangliosides are complex glycosphingolipids crucial for neuronal function.
    • Avoidance conditioning is a learning paradigm that can induce neuroplastic changes.

    Purpose of the Study:

    • To investigate the impact of Sidman avoidance conditioning on brain ganglioside composition in rats.
    • To identify specific brain regions and ganglioside types affected by this learning task.

    Main Methods:

    • Rats were trained on a 30-day Sidman avoidance task following intracerebral (14C) acetate injection.
    • Ganglioside fractions were isolated from various brain regions (neocortex, hippocampus, brain stem, cerebellum, residual tissue).
    • Radioactivity and ganglioside levels (G1, G2, G3) were quantified and compared between trained and control groups.

    Related Experiment Videos

    Main Results:

    • Trained rats exhibited elevated levels of (14C)-labeled polysialogangliosides (G1, G2, G3) in the hippocampus and neocortex compared to controls.
    • A significant increase in G2 gangliosides was observed in the residual cerebral tissue of trained rats.
    • Ganglioside alterations were region-specific, indicating differential effects of conditioning.

    Conclusions:

    • Sidman avoidance conditioning selectively alters polysialoganglioside levels in specific brain areas, notably the hippocampus and neocortex.
    • Sialic acid-rich gangliosides appear to be particularly sensitive to the neurobiological demands of avoidance learning.
    • These findings contribute to understanding the molecular basis of learning and memory consolidation.