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Histopathological changes in aluminium phosphide poisoning

B Arora1, R S Punia, R Kalra

  • 1Department of Pathology, Medical College and Hospital, Rohtak.

Journal of the Indian Medical Association
|October 1, 1995
PubMed
Summary

This study examined thirty cases of aluminium phosphide poisoning, revealing significant cellular hypoxia and organ damage. Lungs, kidneys, and adrenals showed the most severe histopathological changes.

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Area of Science:

  • Toxicology
  • Pathology
  • Medical Science

Background:

  • Aluminium phosphide (AlP) is a highly toxic pesticide.
  • AlP poisoning is a significant cause of mortality worldwide.
  • Understanding the pathological effects of AlP is crucial for clinical management.

Purpose of the Study:

  • To investigate the gross and microscopic pathological changes in organs following aluminium phosphide poisoning.
  • To identify the organs most severely affected by AlP toxicity.

Main Methods:

  • A study of thirty cases of aluminium phosphide poisoning.
  • Gross examination of organs including lungs, liver, kidneys, heart, brain, stomach, and adrenals.
  • Microscopic examination (histopathology) of affected tissues.

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Main Results:

  • Histopathological findings included congestion, edema, and leucocytic infiltration in various organs.
  • These changes were indicative of cellular hypoxia.
  • Lungs, kidneys, and adrenals exhibited the most pronounced pathological effects.

Conclusions:

  • Aluminium phosphide poisoning causes significant cellular hypoxia.
  • The lungs, kidneys, and adrenals are primary targets for AlP-induced organ damage.
  • Detailed histopathological analysis is essential for understanding AlP toxicity.