[Study on the penetration of ceftriaxone into cerebrospinal fluid]

Concentrations of ceftriaxone (CTRX) in the serum and the cerebrospinal fluid (CSF) were serially investigated after an intravenous drip infusion of 2 g per day to 14 patients with acute cerebrovascular diseases, as they were determined at 30 minutes, 3, 6, 24 hours, 3 and 7 days after first administration. The results obtained are summarized as follows: 1. Serum levels; Peak levels of CTRX in the serum were 162.0 +/- 51.2 (SD) micrograms/ml at 30 minutes after administration. Even at 24 hours after intravenous drip infusion, concentrations of CTRX were 14.9 +/- 6.15 (SD) micrograms/ml. 2. CSF levels; The CTRX concentrations in the CSF rose to 1.70 +/- 1.84 (SD) micrograms/ml at 30 minutes, 3.51 +/- 3.31 (SD) micrograms/ml at 3 hours and then decreased to 0.74 +/- 0.67 (SD) micrograms/ml at 24 hours after first infusion. 3. CTRX concentrations in serum in CSF after serially repeated infusion for 3 to 7 days were quite similar to the those obtained after the first administration. The above results indicates that CTRX is useful for the prevention of postoperative infections in the field of neurosurgery.