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Related Experiment Videos

The new obesity genes

S B Roberts1, A S Greenberg

  • 1Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

Nutrition Reviews
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence obesity susceptibility. Research has identified several candidate obesity genes in both animal models and humans, but further investigation is needed to understand their role in diverse populations.

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Area of Science:

  • Genetics
  • Obesity Research
  • Human Physiology

Background:

  • Individual susceptibility to obesity is strongly linked to genetic inheritance.
  • Candidate obesity genes influencing body fat mass and distribution have been identified.
  • Genetic basis for obesity established in animal models (Ob/Ob mouse, Fat mouse, Yellow mouse).

Purpose of the Study:

  • To review the current understanding of genetic factors contributing to human obesity.
  • To highlight identified candidate obesity genes and their potential roles.
  • To emphasize the need for further research into gene variations and population-specific environmental interactions.

Main Methods:

  • Review of genetic studies in animal models of obesity.
  • Analysis of human genetic studies identifying sequence variations linked to obesity and fat distribution.

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  • Synthesis of current knowledge on candidate obesity genes.

    • Main Results:

    • Genetic basis for obesity identified in specific mouse models.
    • Sequence variations in at least six genes linked to increased body fatness in humans.
    • Five additional genes associated with disproportionate abdominal fat storage identified in humans.

    Conclusions:

    • Identified human genes are considered modifying or background genes, each conferring a modest increase in obesity susceptibility.
    • Further research is crucial to identify additional candidate genes for obesity.
    • Determining the relative importance of these genes across diverse human populations and environments is essential.