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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[Heart murmurs associated with organic murmurs]
Insights
Congenital heart disease patients often show atypical heart murmur sound oscillations due to unique intracardiac structures. These findings suggest underlying morphofunctional peculiarities contribute to murmurs in congenital heart disease.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Echocardiography
Context:
- Congenital heart disease (CHD) affects intracardiac structures.
- Typical organic murmurs in CHD can present atypically.
- Echocardiographic and clinical examinations are crucial for diagnosis.
Purpose:
- To investigate the characteristics of heart murmurs in patients with congenital heart disease.
- To identify atypical sound oscillations in specific types of CHD.
- To explore the association between intracardiac structural peculiarities and murmur formation.
Summary:
- A study of 157 congenital heart disease patients revealed atypical sound oscillations in 42.3% of cases with interventricular septal defect, interatrial septal defect, or patent ductus arteriosus.
- These atypical murmurs are believed to originate from unique morphofunctional peculiarities of intracardiac structures.
- Such peculiarities are hypothesized to be associated factors in the generation of cardiac murmurs and residual murmurs post-correction.
Impact:
- Highlights the complex nature of heart murmurs in congenital heart disease.
- Suggests a need for advanced diagnostic approaches considering intracardiac structural variations.
- Informs clinical understanding and management strategies for congenital heart defects.
Abstract:
157 patients with congenital heart disease were examined clinically and echocardiographically. Patients with interventricular septal defect, interatrial septal defect or patent ductus arteriosus having typical organic murmur exhibited atypical sound oscillations forming concording epicenter (42.3% of patients). It is believed that all patients with congenital heart disease have additional morphofunctional peculiarities of intracardiac structures. It is thought that these are associated factors forming cardiac murmurs and residual murmurs after the disease correction.
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