Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lactic acidosis and other mitochondrial disorders

P W Stacpoole1

  • 1Department of Medicine, University of Florida College of Medicine, Gainesville, USA.

Metabolism: Clinical and Experimental
|March 1, 1997
PubMed
Summary

Mitochondrial dysfunction, marked by lactic acidosis, impacts cell survival and homeostasis. Therapies targeting mitochondrial energy production could treat various clinical disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.

Journal of clinical pharmacology·2014
Same author

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

Investigational new drugs·2013
Same author

Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells.

Gene therapy·2011
Same author

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Neurology·2006
Same author

Metabolic complications of severe malaria.

Current topics in microbiology and immunology·2005
Same author

Effects of alginate encapsulation on mitochondrial activity.

Journal of materials science. Materials in medicine·2005

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathophysiology

Background:

  • Mitochondria are vital for cellular energy production and homeostasis.
  • Mitochondrial dysfunction can lead to energy failure and disease.
  • Lactic acidosis is a key indicator of impaired mitochondrial function.

Purpose of the Study:

  • To highlight the broad clinical relevance of mitochondrial dysfunction beyond lactic acidosis.
  • To underscore the therapeutic potential of interventions aimed at improving mitochondrial energy production.

Main Methods:

  • This abstract does not detail specific methods.
  • It focuses on the conceptual framework of mitochondrial function in disease.

Main Results:

  • Lactic acidosis is a prominent but not exclusive sign of mitochondrial oxidative phosphorylating defects.
  • Abnormalities in mitochondrial capacity contribute to diverse clinical conditions.

Conclusions:

  • Mitochondrial dysfunction is implicated in a wide range of diseases.
  • Enhancing mitochondrial function or preventing energy failure offers promising therapeutic avenues.

Related Experiment Videos