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Septal function during left ventricular unloading

M R Moon1, A F Bolger, A DeAnda

  • 1Department of Cardiovascular and Thoracic Surgery, Stanford (Calif) University School of Medicine 94305, USA.

Circulation
|March 4, 1997
PubMed
Summary
This summary is machine-generated.

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Left ventricular unloading negatively impacts septal function. This reduction in septal systolic thickening and output may worsen right ventricular contractility during mechanical left ventricular support.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Mechanical circulatory support for the left ventricle (LV) is known to alter heart chamber geometry and reduce right ventricular (RV) function.
  • The specific impact of LV unloading on the systolic function of the interventricular septum has not been previously investigated.

Purpose of the Study:

  • To investigate the effects of LV volume and pressure unloading on interventricular septal geometry and systolic function.

Main Methods:

  • Seven open-chest anesthetized dogs underwent LV preload reduction by clamping left atrial pressure.
  • A pressure-control servomechanism was used to withdraw blood from the left atrium, reducing LV preload.
  • Two-dimensional echocardiography was used to assess septal geometry and function.

Related Experiment Videos

Main Results:

  • LV unloading significantly decreased LV pressure and end-diastolic cross-sectional area.
  • The interventricular septum shifted towards the right ventricle, flattened, and its end-diastolic thickness increased.
  • Systolic septal thickening and septal output significantly decreased, indicating impaired systolic function.

Conclusions:

  • Left ventricular unloading alters interventricular septal geometry.
  • LV unloading reduces septal systolic thickening and output.
  • These septal changes may contribute to impaired RV contractility during mechanical LV support.