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Antiperoxidative activity of neolignans from Magnolia obovata
H Haraguchi1, H Ishikawa, N Shirataki
1Faculty of Engineering, Fukuyama University, Japan.
The Journal of Pharmacy and Pharmacology
|February 1, 1997
Abstract:
Honokiol and magnolol, neolignans in Magnolia obovata, have been evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH were inhibited by these compounds. These neolignans protected mitochondrial respiratory chain enzyme activity against NADPH-induced peroxidative stress and protected red cells against oxidative haemolysis. The anti-oxidative activity of honokiol was more potent than that of magnolol. Neolignans in M. obovata were shown to be effective in protecting biological systems and functions against oxidative stress.