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Furanocoumarins with affinity to brain benzodiazepine receptors in vitro
O Bergendorff1, K Dekermendjian, M Nielsen
1Division of Organic Chemistry 2, University of Lund, Sweden.
Phytochemistry
|March 1, 1997
Abstract:
Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.