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Related Experiment Videos

Case study: two additional sudden deaths with tricyclic antidepressants

C K Varley1, J McClellan

  • 1Division of Child and Adolescent Psychiatry, University of Washington, Seattle, USA.

Journal of the American Academy of Child and Adolescent Psychiatry
|March 1, 1997
PubMed
Summary

Two children died suddenly while being treated with tricyclic antidepressants (TCAs). These cases add to concerns regarding the safety of TCAs, like desipramine and imipramine, in pediatric patients.

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Sudden death related to selected tricyclic antidepressants in children: epidemiology, mechanisms and clinical implications.

Paediatric drugs·2001

Area of Science:

  • Pediatric pharmacology
  • Cardiovascular safety in children
  • Adverse drug reactions

Background:

  • Tricyclic antidepressants (TCAs) are used to treat various conditions in children.
  • Previous reports have documented sudden deaths in children on desipramine.
  • Concerns exist regarding the cardiovascular safety of TCAs in pediatric populations.

Observation:

  • This case study details the sudden deaths of two additional children undergoing treatment with TCAs.
  • One child received desipramine at 3.3 mg/kg/day.
  • The second child was treated with imipramine (6 mg/kg/day) and thioridazine (1 mg/kg/day).

Findings:

  • The deaths of these two children, associated with desipramine and imipramine/thioridazine, are presented.
  • These events contribute to the existing body of evidence on TCA-related adverse events in children.

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  • The findings highlight potential risks associated with specific TCA dosages and combinations.

    • Implications:

    • These cases underscore the need for careful monitoring of children treated with TCAs.
    • Further research into the mechanisms of sudden death associated with TCAs in pediatric patients is warranted.
    • Clinicians should weigh the benefits against the risks when prescribing TCAs for pediatric use, considering alternative treatments if necessary.