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Oestrogen receptor deficiency: consequences for growth

E P Smith¹, K S Korach

¹Children's Hospital Medical Centre, Cincinnati, Ohio, USA.

Acta Paediatrica (Oslo, Norway : 1992). Supplement

|October 1, 1996

Summary

Estrogen is the main steroid hormone regulating final height by initiating and completing epiphyseal closure. Androgen also influences pubertal growth, partly through aromatization into estrogen.

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Area of Science:

Endocrinology
Pediatric Endocrinology
Skeletal Biology

Background:

Previous understanding attributed pubertal growth and skeletal maturation primarily to androgens, suggesting sexual dimorphism.
Emerging evidence indicates common mechanisms for pubertal growth in both sexes.

Purpose of the Study:

To elucidate the combined roles of androgens and estrogens in regulating pubertal growth.
To clarify the specific contributions of estrogen to skeletal maturation and final height attainment.

Main Methods:

Analysis of estrogen-resistant and aromatase-deficient cases.
Review of current evidence on sex steroid physiology and pubertal growth.
Consideration of new sensitive assays for estradiol.

Main Results:

Estrogen is identified as the principal steroid hormone driving the final stages of skeletal maturation and epiphyseal closure.
Estrogen deficiency states are not necessarily lethal and can allow prolonged growth with minimal bone-age advancement.
Androgen's effects on height regulation are direct and indirect, including aromatization to estrogen.

Conclusions:

Estrogen plays a critical role as a determinant of final height in children.
A comprehensive understanding of estrogen's role opens new avenues in sex-steroid physiology and pubertal growth research.
Therapeutic interventions using sex steroids for growth manipulation must consider potential adverse effects on bone mineral accretion.

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