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Related Experiment Videos

Depressive dementia: a "transitional dementia"?

V O Emery1, T E Oxman

  • 1Dartmouth Medical School, Lebanon, NH, USA.

Clinical Neuroscience (New York, N.Y.)
|January 1, 1997
PubMed
Summary
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Depression and dementia may exist on a continuum, not as separate conditions. Depressive dementia might be a transitional stage, potentially increasing the risk for degenerative dementia.

Area of Science:

  • Gerontology
  • Neurology
  • Psychiatry

Background:

  • Depression and dementia are often viewed as distinct entities: functional-reversible depression versus organic-irreversible dementia.
  • This dichotomy may oversimplify the complex relationship between these conditions.

Purpose of the Study:

  • To examine the spectrum of depression in dementia.
  • To evaluate the traditional separation of depressive dementia and degenerative dementia.
  • To propose a model of intersecting continua for depression, cognitive impairment, and dementia.

Main Methods:

  • Historical, clinical, and empirical review of depression and dementia.
  • Definition of five prototypical groups along continua of depression and dementia.
  • Analysis of data to understand the progression and relationship between depressive and degenerative dementia.

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Main Results:

  • A subset of major depression cases may evolve into depressive dementia.
  • Depressive dementia can be a risk factor for degenerative dementia.
  • Depressive dementia and degenerative dementia can represent different stages of a single disease process.

Conclusions:

  • Depression, cognitive impairment, and degenerative dementia should be viewed as intersecting continua.
  • Depressive dementia may serve as a transitional stage toward degenerative dementia.
  • The concept of "transitional dementia" is introduced to better classify depressive dementia.