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Related Experiment Videos

Chloramphenicol toxicity in dogs

A D Watson

    Research in Veterinary Science
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Chloramphenicol treatment in dogs caused dose-dependent toxicity, including depression and reduced food intake at higher doses. Bone marrow suppression, particularly of erythropoiesis, was observed at the highest chloramphenicol doses.

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    Area of Science:

    • Veterinary Pharmacology
    • Toxicology

    Background:

    • Chloramphenicol is a broad-spectrum antibiotic used in veterinary medicine.
    • Understanding its toxicological profile in dogs is crucial for safe clinical application.

    Purpose of the Study:

    • To evaluate the toxic effects of orally administered chloramphenicol in dogs.
    • To determine dose-dependent adverse effects on clinical signs and bone marrow.

    Main Methods:

    • Twenty dogs received varying doses of chloramphenicol (75-275 mg/kg/day) for 14 days.
    • Control dogs received placebo capsules.
    • Clinical observations, food consumption, body weight, hematology, and bone marrow examinations were performed.

    Main Results:

    • Dogs receiving 175 mg/kg/day or higher showed decreased food intake and weight loss.

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  • Depression and anorexia were noted in dogs at doses of 175 mg/kg/day and above.
  • Bone marrow examination revealed suppressed erythropoiesis in 4/9 dogs at 225-275 mg/kg/day, with reduced granulocytopoiesis at 275 mg/kg/day.

    • Conclusions:

    • Chloramphenicol exhibits dose-dependent toxicity in dogs, manifesting as clinical signs and bone marrow suppression.
    • Adverse effects, including hypophagia, depression, and hematopoietic suppression, necessitate careful dosage considerations in canine treatment.