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Fluconazole in the management of neonatal systemic candidiasis
A Narang1, P Agrawal, A Chakraborti
1Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh.
Objective:
To evaluate the role of Fluconazole in the management of neonatal systemic candidiasis.
Design:
Descriptive, retrospective analysis.
Subjects:
23 neonates diagnosed as systemic candidiasis based on clinical suspicion with blood and/or urine culture positive for candida were treated with Fluconazole (5 mg/kg/day) for > 7 days.
Results:
Babies had mean birth weight 1590 + 533 g, mean gestation 32.3 + 3.1 wks and fungal sepsis was diagnosed at a mean age of 14.3 + 7.9 days. Candida albicans (43.5%), C. tropicalis (21.7%), C. guillermondii (13%), C. parapsillosis (13%) and C. krusei (8.7%) were the species isolated. Fluconazole was effective in 82.3% cases with no side effects. Four resistant cases were C. parapsillosis (n = 2), C. albicans (n = 1) and C. guillermondii (n = 1) and there were three deaths, all in resistant cases though one death was unrelated to candidemia.
Conclusion:
Fluconazole is a safe and effective drug for neonatal systemic candidiasis.