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Morphine withdrawal and schedule-induced polydipsia

Y P Liu¹, C P Chiang, C J Tseng

¹Military 818 Psychiatry Hospital, Taipei, Taiwan, ROC.

The Chinese Journal of Physiology

|January 1, 1996

Summary

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Morphine dependence and withdrawal alter schedule-induced polydipsia (SIP) in rats. Locus coeruleus lesions and excitatory amino acid pathway inhibition attenuated these effects, suggesting their role in morphine

Area of Science:

Neuroscience
Behavioral Pharmacology
Addiction Research

Background:

Schedule-induced polydipsia (SIP) is a behavior linked to arousal and intermittent feeding schedules.
Morphine dependence and withdrawal are known to cause significant physiological and behavioral changes.

Purpose of the Study:

To investigate the effects of morphine dependence and withdrawal on SIP in rats.
To examine the involvement of the locus coeruleus (LC) and excitatory amino acid (EAA) pathways in these SIP alterations.

Main Methods:

Rats exhibiting SIP were administered incremental morphine doses, followed by naloxone challenge.
Bilateral LC lesions and lateral ventricle kynurenic acid infusions were performed.
Water intake was measured as an indicator of SIP strength.

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Main Results:

Morphine dependence decreased SIP strength.
Morphine withdrawal initially reduced, then increased SIP strength.
Both LC lesions and kynurenic acid administration attenuated the observed SIP changes during morphine withdrawal.

Conclusions:

The locus coeruleus and excitatory amino acid pathways play a role in modulating SIP during morphine dependence and withdrawal.
These findings offer insights into the neurobiological mechanisms underlying morphine withdrawal and SIP performance.