Salazosulfapyridine suppresses chondrocyte mediated degradation induced by interleukin 1beta

¹Central Research Laboratories, Santen Pharmaceutical Co. Ltd., Osaka, Japan.

|March 1, 1997

Abstract

Objective:

To investigate the effects of salazosulfapyridine (SASP) and methotrexate (MTX) on interleukin (IL)-1beta treated rabbit chondrocytes.

Methods:

Normal rabbit chondrocytes were cultured to confluency. IL-1beta was added to serum-free culture medium in the presence or absence of SASP or MTX. After 2 days' incubation, the effects were evaluated from the responses of metalloproteinases, glycosaminoglycan (GAG), and prostaglandin E2 (PGE2).

Results:

SASP and MTX suppressed GAG and collagenase release into the culture medium from IL-1beta stimulated rabbit chondrocytes in a dose dependent manner. Only SASP suppressed stromelysin and PGE2 release.

Conclusion:

SASP may have a protective effect on cartilage degradation of patients with rheumatoid arthritis.

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Salazosulfapyridine suppresses chondrocyte mediated degradation induced by interleukin 1beta

Objective:

Methods:

Results:

Conclusion:

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