Related Experiment Videos
Perinatal lung function and invasive antenatal procedures
B Yüksel1, A Greenough, S Naik
1Department of Child Health, King's College Hospital, London, UK.
Thorax
|February 1, 1997
Summary
First-trimester invasive prenatal procedures like amniocentesis may negatively impact infant lung function. These investigations were linked to higher airway resistance and reduced lung capacity in newborns.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Pulmonology
Background:
- Second-trimester amniocentesis is linked to perinatal lung function issues.
- Early amniocentesis and other first-trimester invasive procedures may pose similar risks.
Purpose of the Study:
- To investigate the impact of early amniocentesis and chorion villus sampling on perinatal lung function.
- To determine if first-trimester invasive procedures are associated with abnormal lung development in infants.
Main Methods:
- Plethysmography measured thoracic gas volume (TGV) and airway resistance (Raw), calculating specific airway conductance (sGaw).
- Functional residual capacity (FRC) was measured using helium gas dilution.
- Study included infants whose mothers had early amniocentesis (n=47), chorion villus sampling (n=19), and controls (n=25).
Main Results:
- Infants of mothers with early amniocentesis showed higher TGV and Raw, and lower sGaw and FRC compared to controls.
- Infants of mothers with chorion villus sampling also had significantly higher Raw and lower sGaw than controls.
- First-trimester procedures were independently associated with increased airway resistance.
Conclusions:
- Invasive procedures during the first trimester of pregnancy appear to adversely affect perinatal lung function.
- These findings highlight potential risks associated with early invasive antenatal investigations.