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Related Experiment Videos

Elevated fibrinogen levels decrease following treatment of acromegaly

K Landin-Wilhelmsen1, L Tengborn, L Wilhelmsen

  • 1Department of Medicine, Sahlgrenska Hospital, Göteborg, Sweden.

Clinical Endocrinology
|January 1, 1997
PubMed
Summary
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Patients with acromegaly have higher fibrinogen levels, increasing cardiovascular and stroke risk. Treatment for acromegaly effectively lowers these elevated fibrinogen levels.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Acromegaly is linked to heightened cardiovascular disease and stroke risks.
  • Fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are implicated in thrombotic events.

Purpose of the Study:

  • To investigate fibrinogen and PAI-1 activity in acromegaly patients.
  • To assess changes in these markers before and after treatment.

Main Methods:

  • Compared 20 acromegaly patients with matched healthy controls.
  • Analyzed fibrinogen and PAI-1 activity.
  • Compared fibrinogen to a large population sample.

Main Results:

  • Acromegalic patients exhibited higher plasma fibrinogen levels compared to controls and the general population.

Related Experiment Videos

  • Plasma fibrinogen positively correlated with serum insulin-like growth factor-I (IGF-I).
  • Fibrinogen levels decreased significantly after acromegaly treatment.

    • Conclusions:

    • Elevated fibrinogen in acromegaly may contribute to increased cardiovascular and stroke risks.
    • Treatment of acromegaly leads to a reduction in fibrinogen levels.