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Arousal and inhibition of human NK cells
L L Lanier1, B Corliss, J H Phillips
1DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA. lanier@dnax.org
Immunological Reviews
|February 1, 1997
Abstract:
NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.