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Sudomotor function in sympathetic reflex dystrophy

F Birklein1, R Sittl, A Spitzer

  • 1Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany.

Pain
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Patients with reflex sympathetic dystrophy (RSD) show enhanced sweating responses and faster onset of sweating on affected limbs compared to unaffected limbs, indicating altered sudomotor output.

Area of Science:

  • Neurology
  • Dermatology
  • Physiology

Background:

  • Reflex sympathetic dystrophy (RSD), now known as Complex Regional Pain Syndrome (CRPS), is a poorly understood condition affecting the nervous system.
  • Sudomotor dysfunction is a recognized but not fully characterized feature of RSD.

Purpose of the Study:

  • To investigate sudomotor (sweating) function in patients with reflex sympathetic dystrophy (RSD).
  • To compare sweating responses and onset latency between affected and unaffected limbs in RSD patients.

Main Methods:

  • Studied 27 RSD patients using local sweating rate measurements via gas-flow chambers and hygrometers.
  • Induced sweating through thermoregulatory challenges (hot tea, infrared irradiation) and axon reflex testing (QSART with carbachol iontophoresis).

Related Experiment Videos

  • Measured skin temperature using infrared thermography.

    • Main Results:

    • Affected limbs showed significantly higher skin temperature but no difference in basal sweating.
    • Both thermoregulatory sweating (TST) and QSART induced significantly greater sweat responses on the affected side.
    • Sweating onset latency was significantly shorter on the affected side under both stimulation conditions.

    Conclusions:

    • RSD involves a differential disturbance of vasomotor and sudomotor mechanisms.
    • While vasoconstrictor activity appears reduced, sudomotor output is either normal or enhanced in affected limbs.
    • Findings suggest altered autonomic nervous system regulation in RSD pathophysiology.