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Related Experiment Videos

Splenic mesothelial cysts mimicking lymphagiomas

D A Arber1, J G Strickler, L M Weiss

  • 1Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, U.S.A.

The American Journal of Surgical Pathology
|March 1, 1997
PubMed
Summary

Splenic tumors resembling lymphangiomas were investigated. Immunohistochemistry revealed these lesions are likely mesothelial in origin, not true lymphangiomas, aiding in accurate diagnosis of splenic tumors.

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Area of Science:

  • Pathology
  • Oncology
  • Histology

Background:

  • Splenic lymphangiomas are rare, presenting as solitary or part of lymphangiomatosis.
  • Traditionally, solitary splenic lymphangiomas are subcapsular, multicystic growths often found incidentally.

Purpose of the Study:

  • To investigate the immunohistochemical profile of splenic tumors morphologically similar to solitary lymphangiomas.
  • To determine the cellular origin of these splenic lesions and differentiate them from true lymphangiomas.

Main Methods:

  • Six cases of splenic tumors with lymphangioma-like features were analyzed.
  • Immunohistochemistry was performed using epithelial, mesothelial, and vascular markers (keratin, HBME-1, Factor VIII-related antigen, CD31, CD34).

Main Results:

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  • None of the patients had evidence of lymphangiomatosis.
  • All studied tumors were incidental findings in splenectomy specimens.
  • Lining cells tested positive for keratin and HBME-1, but negative for vascular markers, indicating a mesothelial origin.

Conclusions:

  • The studied splenic multicystic proliferations are suggested to be of mesothelial derivation.
  • These findings challenge the traditional classification of such lesions as true splenic lymphangiomas.
  • Accurate immunohistochemical analysis is crucial for diagnosing splenic tumors.