Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NMDA receptor antagonists: interactions with opioids

A H Dickenson1

  • 1Department of Pharmacology, University College London, United Kingdom.

Acta Anaesthesiologica Scandinavica
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central Nervous System Targets: Supraspinal Mechanisms of Analgesia.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2020
Same author

Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain.

Neuropharmacology·2019
Same author

Characterisation of peripheral and central components of the rat monoiodoacetate model of Osteoarthritis.

Osteoarthritis and cartilage·2019
Same author

An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis.

Journal of neurophysiology·2018
Same author

The plasticity of descending controls in pain: translational probing.

The Journal of physiology·2017
Same author

An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat.

European journal of pain (London, England)·2016

N-methyl-D-aspartate (NMDA) receptor antagonists can block pain hypersensitivity, offering new treatments for chronic pain conditions. Combining these with opioids may enhance efficacy and reduce side effects in difficult-to-treat pain states.

Area of Science:

  • Neuroscience
  • Pain Research
  • Pharmacology

Background:

  • The N-methyl-D-aspartate (NMDA) receptor is crucial for central hypersensitivity, contributing to pathological pain states.
  • Understanding spinal cord amplification systems, like the NMDA receptor, is key to deciphering pain response variability.

Purpose of the Study:

  • To explore the potential of NMDA receptor antagonists in managing pain, particularly hyperalgesic states.
  • To investigate the synergistic effects of combining NMDA antagonists with opioids for pain management.

Main Methods:

  • Review of controlled clinical studies involving NMDA receptor antagonists (e.g., ketamine).
  • Analysis of the mechanisms underlying NMDA receptor-mediated pain transmission and modulation.

Related Experiment Videos

Main Results:

  • NMDA receptor antagonists show promise in preventing or blocking hyperalgesia induced by various stimuli.
  • Clinical studies support the critical role of NMDA-mediated events in pathological and prolonged pain.
  • Combinations of opioids and NMDA antagonists may offer synergistic pain relief, especially for neuropathic pain, potentially at lower doses.

Conclusions:

  • NMDA receptor antagonists are valuable therapeutic agents for difficult clinical pain, alone or with opioids.
  • Opioid-NMDA antagonist combinations can achieve synergistic effects through pre- and postsynaptic mechanisms, potentially reducing side effects.
  • Further research into indirect NMDA receptor modulation, involving pathways like adenosine, could yield novel pain treatments.