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Tolerance and dependence to opiates

D R Jasinski1

  • 1Johns Hopkins University, Baltimore, Maryland, USA.

Acta Anaesthesiologica Scandinavica
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Opiate addiction involves tolerance and dependence, recognized in the 19th century. Studies from 1929 to 1979 focused on morphine

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Research

Background:

  • Opiate addiction recognized in the 19th century.
  • Systematic investigations into opiate addiction began in the U.S. in 1929.
  • Morphine is the prototype opiate drug.

Purpose of the Study:

  • To highlight key findings on opiate tolerance and dependence.
  • To relate these findings to clinical pain management.

Main Methods:

  • Review of human studies on opiate addiction.
  • Focus on tolerance and dependence to morphine.
  • Historical analysis of research from 1929-1979.

Main Results:

  • Tolerance and dependence are central features of opiate addiction.

Related Experiment Videos

  • Decades of research elucidated mechanisms of morphine tolerance and dependence.
  • Understanding these phenomena is crucial for clinical applications.

    • Conclusions:

    • Historical research provides foundational knowledge on opiate tolerance and dependence.
    • These insights inform the clinical use of opiates in pain management.
    • Continued understanding is vital for addressing addiction and optimizing pain relief.