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Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors
F A Kerdesky1, C D Brooks, K I Hulkower
1Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Bioorganic & Medicinal Chemistry
|February 1, 1997
Abstract:
Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.