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Related Experiment Videos

NSAIDs and the elderly. Toxicity and economic implications

A C Phillips1, R P Polisson, L S Simon

  • 1Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Drugs & Aging
|February 1, 1997
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) pose risks for older adults, with alternatives like paracetamol potentially offering similar benefits for musculoskeletal pain. Careful consideration of NSAID risks versus benefits, including economic factors, is crucial for elderly patient care.

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Area of Science:

  • Geriatric Medicine
  • Pharmacoeconomics
  • Rheumatology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for elderly patients with musculoskeletal pain, despite potential toxicities.
  • Many painful musculoskeletal conditions in older adults are noninflammatory, suggesting alternative analgesics may suffice.
  • The growing elderly population amplifies concerns regarding the economic impact and safety of NSAID use.

Purpose of the Study:

  • To evaluate the benefits and risks of NSAID therapy in older patients.
  • To assess the economic implications of NSAID use in the elderly, including associated costs and potential offsets.
  • To determine judicious NSAID prescribing practices and the role of gastroprotective agents in this population.

Main Methods:

Related Experiment Videos

  • Systematic evaluation of direct, indirect, and intangible costs associated with NSAID use in the elderly.
  • Analysis of cost-effectiveness of NSAIDs compared to analgesics like paracetamol and tramadol.
  • Assessment of the role of misoprostol for prophylaxis of NSAID-induced ulcer disease.

    • Main Results:

    • NSAID therapy benefits must be weighed against significant potential risks in older patients.
    • The total cost of NSAID prescribing includes gastroprotection, monitoring, and adverse event management.
    • Misoprostol may be cost-effective for preventing NSAID-induced ulcers in high-risk elderly individuals.

    Conclusions:

    • NSAIDs can be used judiciously in older patients, with misoprostol recommended for high-risk individuals.
    • Further economic assessments of NSAID use in the elderly population are warranted.
    • Balancing NSAID efficacy in reducing disability and improving quality of life with their associated costs is essential.