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A 2.8 megabase YAC contig spanning D8S339, which is tightly linked to the Werner syndrome locus
R Bruskiewich1, M Schertzer, S Wood
1Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Genome
|February 1, 1997
Abstract:
A number of gene loci, including the locus for Werner syndrome (WRN), map to proximal human chromosome 8p near the genetic marker D8S339. In this report, we present a long range physical map of an approximately 2.8 megabase yeast artificial chromosome contig centred on D8S339. In this map, we localize the WRN-linked polymorphic sequence-tagged sites (STS) D8S339 and D8S1055, as well as a novel polymorphic STS, D8S2297. We also refine the positions of three known gene loci, GTF2E2, GSR, and PPP2CB, relative to the location of WRN within the map.