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Related Experiment Videos

A correction to the exact test based on the Ewens sampling distribution

M Slatkin1

  • 1Department of Integrative Biology, University of California, Berkeley 94720-3140, USA.

Genetical Research
|December 1, 1996
PubMed
Summary

The exact test for neutrality using Ewens sampling distribution was found to be incorrect. A corrected version yields similar results to Watterson's homozygosity test for small samples but differs for larger ones.

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Area of Science:

  • Population genetics
  • Molecular evolution

Background:

  • The Ewens sampling distribution is a key tool in population genetics for neutrality testing.
  • Previous implementations of an exact test for neutrality based on this distribution were found to be flawed.

Purpose of the Study:

  • To identify and correct errors in the exact test for neutrality based on the Ewens sampling distribution.
  • To compare the performance of the corrected test with existing neutrality tests.

Main Methods:

  • Re-evaluation of the probability calculations for allele configurations in the Ewens sampling distribution.
  • Implementation of a corrected exact test for neutrality.
  • Comparison with Watterson's homozygosity test across various sample sizes.

Main Results:

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  • The original exact test incorrectly used ordered allele configurations instead of unordered ones.
  • The corrected exact test shows similar results to Watterson's test for small sample sizes.
  • Substantial differences between the corrected test and Watterson's test emerge with larger sample sizes.

Conclusions:

  • A corrected exact test for neutrality based on the Ewens sampling distribution is now available.
  • The corrected test offers an alternative to existing methods, with performance varying by sample size.
  • Software for the corrected exact test is accessible from the author.