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Marigenol-concentrates comprising Taxol and/or Taxan esters as active substances
Abstract:
Marigen is a Swiss Research Company based in Riehen (Canton of Basle). It has developed and tested a Solubilization System for its phytosteryl ester compounds having antitumor and antiviral/virucidal activity. By formulating spontaneously dispersible concentrates, which comprise such compounds, it is now possible to produce thermodynamically stable, aqueous ultramicroemulsions which achieve outstanding bioavailability and bio-reactivity for the active principles comprised in these Marigenol-Concen-trates. As a consequence, unwanted side-effects are drastically reduced in therapeutical use or even completely absent, and the economy of the system permits a remarkable optimization of the dose-efficacy relationship and hence also of drug safety.