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Enhancement of lithium elimination by multiple-dose sodium polystyrene sulfonate
J G Linakis1, K M Hull, P G Lacouture
1Department of Pediatrics, Rhode Island Hospital, Providence 02903, USA. james-linakis-phd@brown.edu
Objective:
To determine whether multiple doses of sodium polystyrene sulfonate (SPS) enhance the elimination of IV-administered lithium (Li).
Methods:
The study was a placebo-controlled, investigator-unblinded, murine trial of multiple doses of SPS on serum Li concentrations. Seventy-five male CD-1 mice were given IV pretreatment with LiCl (125 mg/ kg) followed by gavage treatments with SPS (5 g/kg/dose) 20, 40, 90, 150, and 210 minutes after LiCl (experimental group) or deionized water at equivalent times (control group). Subgroups of each treatment group were sacrificed at 1, 2, 4, and 6 hours after LiCl administration and blood was collected for Li analysis.
Results:
Statistical analyses indicated that the SPS group had lower serum Li concentrations overall than did the control animals. This difference was apparent at the 2-, 4-, and 6-hour time points.
Conclusion:
In this murine model, repetitive doses of orogastric SPS enhanced the elimination of parenterally administered Li.