[Protection of the mouse digestive tract from the toxic effect of cytosine-arabinoside]

Comparative experiments have demonstrated a qualitative difference of protective effects, observed in peroral application of 2'-desoxycytidine molecular solution and activated carbon suspension with 2'-desoxycytidine molecules adsorbed onto its particles with regard to the toxicity of intraperitoneal injections of cytosine arabinoside in female C57bl/6j mice. In contrast to 2'-deosyxycytidine molecular solution, which reduced all toxic manifestations and protected animals from death, the corpuscular form of the protector only the toxic effect of the antimetabolite on the intestine without affecting other toxic manifestations, the inhibition of hemopoiesis in particular.