[RS3PE syndrome: presentation of two cases]

Area of Science:

• Rheumatology
• Geriatric Medicine
• Clinical Immunology

Background:

• The remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a recently described clinical entity.
• RS3PE syndrome is characterized by acute onset, symmetrical synovitis, pitting edema, and a predilection for elderly individuals.
• Distinguishing RS3PE from other inflammatory arthropathies like rheumatoid arthritis and polymyalgia rheumatica is clinically important.

Observation:

• RS3PE syndrome typically presents with acute onset synovitis.
• A key characteristic is pitting edema, particularly affecting the hands and feet.
• The condition shows a predilection for elderly patients.

Findings:

• RS3PE syndrome is distinguished by its symmetrical synovitis without producing bony erosions.
• Patients with RS3PE syndrome generally experience an excellent prognosis.
• The syndrome is seronegative, meaning rheumatoid factor and anti-CCP antibodies are typically absent.

Implications:

• This benign arthritis form in aging patients requires recognition to avoid misdiagnosis.
• Understanding RS3PE syndrome aids in providing appropriate and timely patient care.
• Further research into the pathogenesis and optimal treatment strategies for RS3PE syndrome is warranted.